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咨询电话：15012456311普卡必利研究前景：在2001年便秘治疗用药的市场规模为2.2亿，2003年增长到3亿左右，到2008年市场销售额已经达到6亿。虽然普卡必利于2009年刚刚在欧洲各个国家上市销售，但业内评估其2010年的销售额zui高可达3亿欧元。同为5-HT4受体激动剂，与西沙必利的药理学比较如前所述。从用药费用比较来说，目前西沙必利每5mg的售价在1元多左右，用于治疗慢性便秘每日的用量为40mg，每日需花费八九元钱。而普卡必利目前原研厂家的售价折算为人民币大概为每2mg 32元左右，按原研厂家的50%计算，仅为16元左右，略高于西沙必利，且一日仅一片。因此，考虑到疗效、用量等各个方面，普卡必利势必会超过西沙必利，成为慢性便秘的用药。
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| Prucalopride | 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide | C18H26ClN3O3 | 367.87 |
| Prucalopride Impurity 1 | 4-amino-5-chloro-3-hydroxy-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide | C18H26ClN3O4 | 383.87 |
| Prucalopride Impurity 2 | 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)benzofuran-7-carboxamide | C18H26ClN3O3 | 365.85 |
| Prucalopride Impurity 3 | 4-acetamido-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide | C20H28ClN3O4 | 409.91 |
| Prucalopride Impurity 4 | 4-amino-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide | C18H27N3O3 | 333.43 |
| Prucalopride Impurity 5 | 4-acetamido-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide | C20H29N3O4 | 375.46 |
| Prucalopride Impurity 6 | 4-amino-5-chloro-N-(1-(3-hydroxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide | C17H24ClN3O3 | 353.84 |
| Prucalopride Impurity 7 | 4-amino-5-chloro-N-(1-propylpiperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide | C17H24ClN3O2 | 337.84 |
| Prucalopride Impurity 8 | 3-(4-(4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)piperidin-1-yl)propyl 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylate | C26H30Cl2N4O5 | 549.45 |
| Prucalopride Impurity 9 | 4-(4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamido)-1-(3-methoxypropyl)piperidine 1-oxide | C18H26ClN3O4 | 383.87 |
| Prucalopride Impurity 10 | 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxamide | C9H9ClN2O2 | 212.63 |
| Prucalopride Impurity 11 | 4-amino-5-chloro-N-(piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide | C14H18ClN3O2 | 295.76 |
| Prucalopride Impurity 12 | (4-amino-5-chloro-2,3-dihydrobenzofuran-7-yl)(1H-imidazol-1-yl)methanone | C12H10ClN3O2 | 263.68 |
| Prucalopride Impurity 13 | N-(5-chloro-7-(1H-imidazole-1-carbonyl)-2,3-dihydrobenzofuran-4-yl)acetamide | C14H12ClN3O3 | 305.72 |
| Prucalopride Impurity 14 | methyl 4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylate | C12H12ClNO4 | 269.68 |
