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深圳远扬化学可提供阿法替尼申报所用全套杂质， 随货附CoA证书，HNMR，MS，HPLC图谱，纯度符合申报要求，阿法替尼杂质为我司优势杂质，长期备有库存，发货快。如需阿法替尼杂质相关详细信息，欢迎我司业务人员获取。

奥拉帕尼Olaparib原是英国生物技术公司KuDOS Pharmaceuticals的药物，2005年阿斯利康将KuDOS公司收购后，继续开发。2014年12月19日阿斯利康的抗癌药奥拉帕尼（olaparib，商品名：Lynparza）“死而复生”，欧盟委员会（EC）已批准Lynparza作为一种单药疗法，用于铂敏感复发性BRCA突变卵巢癌成人患者的维持治疗，该药也成为用于BRCA突变铂敏感复发性卵巢癌的*PARP抑制剂。 
奥拉帕尼（Olaparib）是一种创新的、*口服多聚ADP核糖聚合酶（PARP）抑制剂，PARP可修复DNA损伤，在DNA损伤修复与细胞凋亡中发挥着重要作用。通常DNA双链断裂如果得不到修复，可触发细胞死亡。健康的细胞由于有多条修复断裂DNA的信号通路，PARP抑制剂对其影响不大，而癌细胞发生的一些特定突变，对PARP抑制敏感。PARP与广泛的肿瘤类型相关，这种作用模式，赋予奥拉帕尼治疗具有DNA修复缺陷的广泛肿瘤类型的潜力。尤其是乳腺癌和卵巢癌。2009年《新英格兰医学杂志》和2010年《柳叶刀》杂志均公布药物Olaparib在治疗乳腺癌、卵巢癌及前列腺癌时效果显着。 

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Olaparib

4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

Olaparib Impurity 1

4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one

Olaparib Impurity 2

3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Olaparib Impurity 3

3-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzonitrile

Olaparib Impurity 4

3-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

Olaparib Impurity 5

2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

Olaparib Impurity 6

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzonitrile

Olaparib Impurity 7

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Olaparib Impurity 8

2-methoxy-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid

Olaparib Impurity 9

2-methoxy-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzonitrile

Olaparib Impurity 10

4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-methoxybenzyl)phthalazin-1(2H)-one

Olaparib Impurity 11

4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-hydroxybenzyl)phthalazin-1(2H)-one

Olaparib Impurity 12

4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzoyl)phthalazin-1(2H)-one

Olaparib Impurity 13

4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one

Olaparib Impurity 14

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide

Olaparib Impurity 15

4-(3-(4-acetylpiperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

Olaparib Impurity 16

4-(3-(4-butyrylpiperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

Olaparib Impurity 17

4-(4-fluoro-3-(4-propionylpiperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one

Olaparib Impurity 18

4-(4-fluoro-3-(4-isobutyrylpiperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one

Olaparib Impurity 19

4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-5-fluorobenzyl)phthalazin-1(2H)-one

Olaparib Impurity 20

4-(5-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-2-fluorobenzyl)phthalazin-1(2H)-one

Olaparib Impurity 21

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzohydrazide

Olaparib Impurity 22

3-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzylidene)isobenzofuran-1(3H)-one

Olaparib Impurity 23

4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)-1,2-dihydrophthalazin-1-yl cyclopropanecarboxylate

Olaparib Impurity 24

4-(4-fluoro-3-(4-pivaloylpiperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one

Olaparib Impurity 25

4,4'-(((piperazine-1,4-dicarbonyl)bis(4-fluoro-3,1-phenylene))bis(methylene))bis(phthalazin-1(2H)-one)